DNA Methylation Profiling of Placental Villi from Karyotypically Normal Miscarriage and Recurrent Miscarriage

Placental gene expression patterns during normal pregnancy and recurrent miscarriage

Placental thrombomodulin expression in recurrent miscarriage

BACKGROUND Early pregnancy loss can be associated with trophoblast insufficiency and coagulation defects. Thrombomodulin is an endothelial-associated anticoagulant protein involved in the control of hemostasis and inflammation at the vascular beds and it's also a cofactor of the protein C anticoagulant pathway. DISCUSSION We evaluate the Thrombomodulin expression in placental tissue from spon...

Recurrent miscarriage

Recurrent miscarriages are one or more pregnancy losses before 20-24 weeks of gestation or below a fetal weight of 500 g (Pic. 1). About 1% of women in reproductive age are affected by recurrent miscarriages. The majority of patients are counseled to try to conceive again, and chances are about 60% that the next pregnancy is successful without treatment. However, each additional loss worsens th...

Recurrent miscarriage

Recurrent miscarriages are one or more pregnancy losses before 20-24 weeks of gestation or below a fetal weight of 500 g (Pic. 1). About 1% of women in reproductive age are affected by recurrent miscarriages. The majority of patients are counseled to try to conceive again, and chances are about 60% that the next pregnancy is successful without treatment. However, each additional loss worsens th...

Recurrent miscarriage

Miscarriage is one of the most common complications of pregnancy. Fifteen percent of clinically recognized pregnancies end in miscarriage. The major cause of spontaneous miscarriage is genetic or developmental abnormalities of the foetus. Recurrent miscarriage occurs in 3% of the population and has been associated with thrombophillias, infections and endocrine, anatomical and immune factors. Tr...